-
Biosketch
Assistant Professor - IIT Palakkad : June 2021 - Present
Research Experience
University of Pittsburgh, USA (Advisor: Prof. Peng Liu) : Nov. 2020 - June 2021
Georg-August Universität Göttingen, Germany (Advisor: Prof. Lutz Ackermann) : June 2018 - Oct. 2020
Education
PhD - Institut Català d'Investigació Química (ICIQ), Barcelona Institute of Science and Technology (BIST), Spain (Advisor: Prof. Feliu Maseras) : 2013 - 2017
EU-COST International Shortstay - Heriot-Watt University, Scotland, UK (Advisor: Prof. Stuart Macgregor) : 2015
MSc in Chemistry - IIT Bombay, India (Advisor: Prof. R. B. Sunoj) : 2011 - 2013
-
Research
Mechanistic understanding of the catalytic reaction has been an important and active field of research in computational organic chemistry. The quantum mechanical understanding of catalytic reactions enable us to design new catalyst and predict new reaction mechanisms. Currently, in silico catalyst design is of great interest in generating the key structural motifs in highly demanding natural products and pharmacophores. We employ state of the art computational techniques of quantum mechanics and molecular mechanics to gather an electronic level understanding of the inherent mechanistic details of various reactions ranging from small molecule activation, asymmetric catalysis, bio mimetic reactions, C-H activation, etc. These findings will drive our way to design novel organo- and transition metal catalytic systems and artificial metalloenzymes, which aligns with our environmentally benign and economically attractive research motto for the generation of molecules of our interest.
-
Teaching
CY5015 - Atomic and Molecular Structure (2021, 2022)
CY1140 - BTech Chemistry Lab
CY1021 - Theoretical and Inorganic Chemistry
CY1040 - BTech Chemistry Lab
CY1040 - Basic Chemistry for Engineers (2022)
-
Research Group
Abra Mathew - PhD ( MSc from MG University)
Krishnapriya A. U - PhD (MSc from Central University Tamilnadu)
Munaifa Arif - MSc Project Student (CUSAT)
Mis Ab V. P - Internship Student (IIT Palakkad)
Alumni
Majma K - Summer Intern (IISER - TVM)
Jibin Thomas - Summer Intern (IISER - TVM)
Nikhil Mondal - MSc Student (IIT Palakkad)
Sujoy Kumar Sarkar - MSc Student (IIT Palakkad)
Basila Hassan - MSc Project Student (Farook College)
Aleena Raihan - MSc Project Student (Farook College)
Vidya Viswanath - MSc Project Student (MG University)
Athul S. B - Research Assistant (IISER-TVM)
-
Additional Information
TitlePublicationsDescription
1. Sil, S.; Bhaskaran, A. S.; Chakraborty, S.; Singh, B.; Kuniyil, R.*; Mandal, S. K*. ‘’Reduced-Phenalenyl-Based Molecule as a Super Electron Donor for Radical-Mediated C–N Coupling Catalysis at Room Temperature’’ J. Am. Chem. Soc. 2022, DOI: https://doi.org/10.1021/jacs.2c09225
2. Trammel G. R.; Kuniyil, R.; Crook. P. F.; Liu. P.; Brown, M. K. ‘’Nickel-Catalyzed Dearomative Arylboration of Indoles: Regioselective Synthesis of C2-and C3-Borylated Indolines’’ J. Am. Chem. Soc. 2021, 143, 16502-16511
3. Zhang, S. K; Vecchio, A. D.; Kuniyil, R.; Messinis, A. M.; Lin, Z.; Ackermann, L. "Electrocatalytic C–H phosphorylation through nickel (III/IV/II) catalysis" Chem. 2021, 7, 1379-1392
4. Shen, Z.; Maksso, I.; Kuniyil, R.; Rogge, T.; Ackermann, L. "Rhodaelectro-catalyzed chemo-divergent C–H activations with alkylidene cyclopropanes for selective cyclopropylations" Chem. Commun. 2021, 57, 3668-3671
5. Liu, J. B.; Wang, X.; Messinis, A. M.; Liu, X. J.; Kuniyil, R.; Chen, D. Z.; Ackermann, L. "Understanding the unique reactivity patterns of nickel/JoSPOphos manifold in the nickel-catalyzed enantioselective C–H cyclization of imidazoles" Chem. Sci. 2021 12, 718-729
6. Wang, W.; Wu, J.; Kuniyil, R.; Lima, R. N.; Ackermann, L. "Peptide Late-Stage Diversifications by Rhodium-Catalyzed Tryptophan C7 Amidation" Chem. 2020, 6, 3428-3439
7. Yang, L.; Jei, B. B.; Scheremetjew, A.; Kuniyil, R.; Ackermann, L. "Electrochemical B–H Nitrogenation: Access to Amino Acid and BODIPY-Labeled nido-Carboranes" Angew. Chem. Int. Ed. 2020, 60, 1482-1487
8. Choi, I.; Müller, V.; Wang, Y.; Xue, K.; Kuniyil, R.; Andreas, L. B.; Karius, V.; Alauzun, J. G.; Ackermann, L. "Recyclable Ruthenium Catalyst for Distal meta-C–H Activation" Chem. Eur. J. 2020, 26, 15290
9. Rogge, T.; Oliveira, J.; Kuniyil, R.; Hu, L.; Ackermann, L. "Reactivity-Controlling Factors in Carboxylate-Assisted C–H Activation under 4d and 3d Transition Metal Catalysis" ACS Catal. 2020, 10, 10551-10558
10. Korvorapun, K.; Struwe, J.; Kuniyil, R.; Zangarelli, A.; Casnati, A.; Waeterschoot, M.; Ackermann, L. "Photo-Induced Ruthenium-Catalyzed C–H Arylations at Room Temperature" Angew. Chem. Int. Ed. 2020, 59, 18103-18109
11. Bu, Q.;* Kuniyil, R.;* Zhigao, S.; Gońka, E.; Ackermann, L. "Insights into Ruthenium(II/IV)-Catalyzed Distal C–H Oxygenation by Weak Coordination" Chem. Eur. J. 2020, 26, 16450 (*contributed equally)
12. Yang, L.; Steinbock, R.; Scheremetjew, A.; Kuniyil, R.; Finger, L. H.; Messinis, A.; Ackermann, L. "Aza-Ruthena(II)-Bicyclo-[3.2.0]-Heptadiene: Key Intermediate for Ruthenaelectro(II/III/I)-Catalyzed Alkyne Annulations" Angew. Chem. Int. Ed. 2020, 59, 11130-11135
13. Liang, Y.-F.; Yang, L.; Jei, B. B.; Kuniyil, R.; Ackermann, L. "Regioselective B(3,4)–H Arylation of o-Carboranes by Weak Amide Coordination at Room Temperature" Chem. Sci. 2020, 11, 10764-10769
14. Zhu, C.; Kuniyil, R.; Jei, B. B.; Ackermann, L. "Domino C–H Activation/Directing Group Migration/Alkyne Annulation: Unique Selectivity by d6-Cobalt(III) Catalysts" ACS Catal. 2020, 10, 4444-4450
15. Massignan, L.; Tan, X.; Meyer, T. H.; Kuniyil, R.; Messinis, A. M.; Ackermann, L. "C−H Oxygenation Reactions Enabled by Dual Catalysis with Electrogenerated Hypervalent Iodine Species and Ruthenium Complexes" Angew. Chem. Int. Ed. 2020, 59, 3184-3189
16. Korvorapun, K.; Kuniyil, R.; Ackermann, L. "Late-Stage Diversification by Selectivity Switch in meta-C–H Activation: Evidence for Singlet Stabilization" ACS Catal. 2020, 10, 435-440
17. Xu, Z.; Huang, Z.; Li, Y.; Kuniyil, R.; Zhang, C.; Ackermann, L.; Ruan, Z. "Catalyst-Free, Direct Electrochemical Synthesis of Annulated Medium-Sized Lactams through C‒C Bond Cleavage" Green Chem. 2020, 22, 1099-1104
18. Gońka, E.; Yang, L.; Steinbock, R; Pescaioli, F.; Kuniyil, R.; Ackermann, L. "π-Extended Polyaromatic Hydrocarbons by Sustainable Alkyne Annulations through Double C–H/N–H Activation" Chem. Eur. J. 2019, 25, 16246-16250
19. Kong, W.-J.; Finger, L. H.; Messinis, A. M.; Kuniyil, R.; Oliveira, J. C. A.; Ackermann, L. "Flow Rhodaelectro-Catalyzed Alkyne Annulations by Versatile C−H Activation: Mechanistic Support for Rhodium(III/IV)" J. Am. Chem. Soc. 2019, 141, 17198-17206
20. Virelli, M.; Wang, W.; Kuniyil, R.; Wu, J.; Zanoni, G.; Fernandez, A.; Scott, J.; Vendrel, M.; Ackermann, L. "BODIPY-Labeled Cyclobutanes by Secondary C(sp3)─H Arylations for Live-Cell Imaging" Chem. Eur. J. 2019, 25, 12712-12718
21. Zhu, C.; Kuniyil, R.; Ackermann, L.; "Manganese(I)-Catalyzed C–H Activation/Diels-Alder/retro-Diels-Alder Domino Alkyne Annulation by Transformable Pyridines" Angew. Chem. Int. Ed. 2019, 58, 5338-5342
22. Lorion, M. M.; Kaplaneris, N.; Son, J.; Kuniyil, R.; Ackermann, L. "Late-Stage Peptide Diversification by Cobalt-Catalyzed C–H Activation: Sequential Multicatalysis for Stapled Peptides" Angew. Chem. Int. Ed. 2019, 58, 1684-1702
23. Dias, G. G.; Rogge, T.; Kuniyil, R.; Jacob, C.; Menna-Barreto, R. F. S.; da Silva Júnior, E. N.; Ackermann, L. "Ruthenium-catalyzed C–H oxygenation of quinones by weak O-coordination for potent trypanocidal agents" Chem. Commun. 2018, 54, 12840-12843
24. Simonetti, M.; Kuniyil, R.; Macgregor, S.; Larrosa, I. "Benzoate cyclometalation enables oxidative addition of haloarenes at a Ru (II) center" J. Am. Chem. Soc, 2018, 140, 11836-11847
25. Guo, W.; Kuniyil, R.; Gómez, J. E.; Maseras, F.; Kleij, A. W. A "Domino Process toward Functionally Dense Quaternary Carbons through Pd-Catalyzed Decarboxylative C(sp3)–C(sp3) Bond Formation" J. Am. Chem. Soc. 2018, 140, 3981-3987 (front cover page)
26. Kuniyil, R.; Maseras, F. "Computational study on the mechanism of the reaction of carbon dioxide with siloxy silanes" Theor. Chem. Acc. 2017, 136, 1-7
27. Guo, W.; Rodríguez, L. M.; Kuniyil, R.; Martin, E.; Adan, E. C. E.; Maseras, F.; Kleij, A. W. "Stereoselective and Versatile Preparation of Tri-and Tetrasubstituted Allylic Amine Scaffolds under Mild Conditions" J. Am. Chem. Soc, 2016, 138, 11970-11978
28. Kuniyil, R.; Sunoj, R. B. "N-Heterocyclic Carbene Catalyzed Asymmetric Intermolecular Stetter Reaction: Origin of Enantioselectivity and Role of Counterions" Org. Lett. 2013, 15, 5040-5043
TitleFundingDescriptionInstitute Seed Grant
DST-SERB Start-up Research Grant (SRG) 2022
-
Publications
Datta, P.; Goswami, T.; Kandoth, N.; Banik, A.; Ahmed, J.; Bhaskaran, A. S.; Saha, R.; Kuniyil, R.; Ghosh, H. N.; Mandal, S. KChemPhotoChem (2023)Sil, S.; Bhaskaran, A. S.; Chakraborty, S.; Singh, B.; Kuniyil, R.; Mandal, S. KJ. Am. Chem. Soc. 2022 144 22611–22621 (2022)Liu, J. B.; Wang, X.; Messinis, A. M.; Liu, X. J.; Kuniyil, R.; Chen, D. Z.; Ackermann, L.Chem. Sci. 12 718-729 (2021)Shen, Z.; Maksso, I.; Kuniyil, R.; Rogge, T.; Ackermann, L.Chem. Commun. 57 3668-3671 (2021)Zhang, S. K; Vecchio, A. D.; Kuniyil, R.; Messinis, A. M.; Lin, Z.; Ackermann, L.Chem 7 1379-1392 (2021)Trammel G. R.; Kuniyil, R.; Crook. P. F.; Liu. P.; Brown, M. K.J. Am. Chem. Soc. 143 16502–16511 (2021)Choi, I.; Müller, V.; Wang, Y.; Xue, K.; Kuniyil, R.; Andreas, L. B.; Karius, V.; Alauzun, J. G.; Ackermann, L.Chem. Eur. J. 26 15290 (2020)Yang, L.; Jei, B. B.; Scheremetjew, A.; Kuniyil, R.; Ackermann, L.Angew. Chem. Int. Ed. 60 1482-1487 (2020)Xu, Z.; Huang, Z.; Li, Y.; Kuniyil, R.; Zhang, C.; Ackermann, L.; Ruan, Z.Green Chem. 22 1099-1104 (2020)Massignan, L.; Tan, X.; Meyer, T. H.; Kuniyil, R.; Messinis, A. M.; Ackermann, L.Angew. Chem. Int. Ed. 59 3184-3189 (2020)Massignan, L.; Tan, X.; Meyer, T. H.; Kuniyil, R.; Messinis, A. M.; Ackermann, L.Angew. Chem. Int. Ed. (59) 3184-3189 (2020)Zhu, C.; Kuniyil, R.; Jei, B. B.; Ackermann, L.ACS Catal. 10 4444-4450 (2020)Liang, Y.-F.; Yang, L.; Jei, B. B.; Kuniyil, R.; Ackermann, L.Chem. Sci. 11 10764-10769 (2020)Yang, L.; Steinbock, R.; Scheremetjew, A.; Kuniyil, R.; Finger, L. H.; Messinis, A.; Ackermann, L.Angew. Chem. Int. Ed. 59 11130-11135 (2020)Bu, Q.; Kuniyil, R.; Zhigao, S.; Gońka, E.; Ackermann, L.Chem. Eur. J. (26) 16450 (2020)Korvorapun, K.; Struwe, J.; Kuniyil, R.; Zangarelli, A.; Casnati, A.; Waeterschoot, M.; Ackermann, L.Angew. Chem. Int. Ed. 59 18103-18109 (2020)Rogge, T.; Oliveira, J.; Kuniyil, R.; Hu, L.; Ackermann, L.ACS Catal. 10 10551-10558 (2020)Wang, W.; Wu, J.; Kuniyil, R.; Lima, R. N.; Ackermann, L.Chem. 6 3428-3439 (2020)Lorion, M. M.; Kaplaneris, N.; Son, J.; Kuniyil, R.; Ackermann, L.Angew. Chem. Int. Ed. 58 1684-1702 (2019)Zhu, C.; Kuniyil, R.; Ackermann, L.Angew. Chem. Int. Ed. 58 5338-5342 (2019)Virelli, M.; Wang, W.; Kuniyil, R.; Wu, J.; Zanoni, G.; Fernandez, A.; Scott, J.; Vendrel, M.; Ackermann, L.Chem. Eur. J. 25 12712-12718 (2019)Kong, W.-J.; Finger, L. H.; Messinis, A. M.; Kuniyil, R.; Oliveira, J. C. A.; Ackermann, L.J. Am. Chem. Soc. 141 17198-17206 (2019)Gońka, E.; Yang, L.; Steinbock, R; Pescaioli, F.; Kuniyil, R.; Ackermann, L.Chem. Eur. J. 25 16246-16250 (2019)Guo, W.; Kuniyil, R.; Gómez, J. E.; Maseras, F.; Kleij, A. W. AJ. Am. Chem. Soc. 140 3981-3987 (2018)Simonetti, M.; Kuniyil, R.; Macgregor, S.; Larrosa, IJ. Am. Chem. Soc. 140 11836-11847 (2018)Dias, G. G.; Rogge, T.; Kuniyil, R.; Jacob, C.; Menna-Barreto, R. F. S.; da Silva Júnior, E. N.; Ackermann, L.Chem. Commun. 54 12840-12843 (2018)Kuniyil, R.; Maseras, F.Theor. Chem. Acc. 136 1-7 (2017)Guo, W.; Rodríguez, L. M.; Kuniyil, R.; Martin, E.; Adan, E. C. E.; Maseras, F.; Kleij, A. W.J. Am. Chem. Soc. 138 11970-11978 (2016)Kuniyil, R.; Sunoj, R. B.Org. Lett. 15 5040-5043 (2013)
